The Notch1/CSL Luciferase Reporter HEK293 Cell Line is a HEK293 cell line that expresses the firefly luciferase reporter under the control of Notch-response elements (CSL responsive elements) and expression of Notch1DE (Notch1 that has a deletion of the entire extracellular domain). Inside the cells, the Notch1DE can be cleaved by γ-secretase. This active Notch1 NICD (Notch intracellular domain) translocated to the nucleus and induces the expression of the luciferase reporter. The cell line is validated for the inhibition of the expression of luciferase reporter using a known inhibitor of the Notch signaling pathway.

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