The transforming growth factor beta (TGFβ)-Responsive SBE Reporter HEK293 Cell Line contains a stably integrated Firefly luciferase gene under the control of SMAD-responsive elements (SMAD binding elements, SBE). This cell line monitors the activity of the TGFβ/SMAD Signaling Pathway.

It is activated in response to human TGFβ1 and to the agonist Activin A. Luciferase activity induced by human TGFβ1 is decreased by SB525334, an inhibitor of TGFβ1-receptor.

Figure 1: illustration of TGFβ/SMAD Signaling Pathway SBE Reporter HEK293 Cell Line.

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